Intermediate of Azacitidine

Intermediate of Azacitidine - Names and Identifiers

Name	2',3',5'-Triacetyl -azacytidine
Synonyms	Nsc291930 Intermediate of Azacitidine 2',3',5'-Triacetyl -azacytidine 2',3',5'-triacetyl-5-Azacytidine 2',3',5'-triacetyl-5-Azacytosine 2'',3'',5''-Triacetyl -Azacytidine 2'',3'',5''-Triacetyl -azacytidine 4-amino-1-(2,3,5-tri-O-acetylpentofuranosyl)-1,3,5-triazin-2(1H)-one 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)- S-Triazin-2(1H)-one, 4-amino-1-.beta.-D-ribofuranosyl-, triacetate (ester) 1,3,5-Triazin-2(1H)-one, 4-aMino-1-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)- 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-o-acetyl-.beta.-D-ribofuranosyl)- (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate
CAS	10302-78-0
InChI	InChI=1/C14H18N4O8/c1-6(19)23-4-9-10(24-7(2)20)11(25-8(3)21)12(26-9)18-5-16-13(15)17-14(18)22/h5,9-12H,4H2,1-3H3,(H2,15,17,22)

Intermediate of Azacitidine - Physico-chemical Properties

Molecular Formula	C14H18N4O8
Molar Mass	370.31
Density	1.60±0.1 g/cm3(Predicted)
Boling Point	497.3±55.0 °C(Predicted)
Flash Point	254.6°C
Vapor Presure	5E-10mmHg at 25°C
pKa	3.06±0.20(Predicted)
Storage Condition	Keep in dark place,Inert atmosphere,2-8°C
Refractive Index	1.633
Physical and Chemical Properties	Storage Conditions: Store at 0-5 ℃

Intermediate of Azacitidine - Introduction

Triacetyl -5-, also known as 3-acetylamino-5-aza-1-Δ4-piperidinone nucleoside (azacytidine nucleoside), is a nucleoside compound. The following is a description of its nature, use, formulation and safety information:

Nature:
Triacetyl-5-azacytidine is a white crystalline solid that is stable at ambient temperature. It has a strong polarity, soluble in water and organic solvents. Its chemical structure contains nitrogen and amide functional groups, which make it have special chemical and biological activities.

Use:
Triacetyl -5-azacytidine is mainly used as a pharmaceutical intermediate and research reagent. In the field of medicine, it is used to synthesize antiviral drugs, such as anti-HIV drugs. In the field of scientific research, it is often used to synthesize biologically active molecules or heterocyclic compounds. In addition, it can also be used for DNA synthesis and virus suppression.

Preparation Method:
Triacetyl -5-azacytidine is generally obtained by chemical synthesis. Common methods of preparation include synthesis of nucleotides and chemical modification of functional groups. The specific preparation method can be selected according to the desired purity and scale.

Safety Information:
Triacetyl-5-azacytidine is less toxic and dangerous, but it is still a chemical substance that needs to be handled correctly in the laboratory. When handling, take appropriate protective measures, such as wearing gloves and protective glasses, to avoid inhalation or contact with the skin. If ingested by mistake or into the eyes or skin, rinse immediately with plenty of water and seek medical help. In addition, the compound should be stored in a dry, cool, well-ventilated place, away from fire sources and flammable materials. During use and storage, be sure to carefully read and follow the relevant safety data sheets and instructions for use.

Last Update：2024-04-09 20:52:54

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